DCIS grad 3 enn for DCIS grad 1 og 2 (58;59) Diffust utbredt enn for mikrofokale; Hos yngre kvinner (60) Størrelse. Det er vist at residivfaren øker med størrelse, men det kan være vanskelig å få gode data på størrelse og residivfrekvens, på grunn av vanskelig målbarhet av lesjonen, ofte flere etterfølgende inngrep og heterogenitet i. DCIS wordt op basis van de celpatronen ingedeeld 3 groepen: Graad I / II / III. De verschillende groepen DCIS zijn apart ingedeeld op basis van hun biologisch gedrag een DCIS graad I zal indien dit zich onverhoopt toch zou ontwikkelen tot borstkanker, meest waarschijnlijk eerder een graad I borstkanker worden dan een graad III borstkanker en andersom . 30% av disse ved endelig histologi likevel foreligger en invasiv brystkreft og de vil således kunne spares for en VL operasjon i et nytt inngrep. Hos alle med DCIS (ductalt carcinoma in situ) grad 3 hvor det skal gjøres ablatio, bør VL gjøres da man ikk
Brystkreft er den vanligste kreftformen blant kvinner. Fire av fem som rammes er over 50 år, og arv øker risikoen for å utvikle brystkreft Die Abschätzung der Brustkrebs-Prognose hängt von einer Reihe von Tumormerkmalen ab, darunter die Tumorgröße, der Tumortyp sowie der Grad der Bösartigkeit des Tumors. Um das Rückfallrisiko bei Brustkrebs zu bestimmen, werden Patientinnen unter Berücksichtigung der verschiedenen gesicherten Faktoren für die Brustkrebs-Prognose in drei Risikogruppen (niedriges, mittleres und hohes Risiko.
Nach der Diagnostizierung eines DCIS ist der erste Schritt für gewöhnlich ein chirurgischer Eingriff zur Entfernung des DCIS. Im nächsten Schritt gilt es einzuschätzen, wie hoch das Risiko ist, dass der Tumor entweder als DCIS oder als invasiver Brustkrebs in derselben Brust erneut auftritt (dies nennt man Lokalrezidiv) PAD visat dcis 10 mm grad 3 med nekros, extent 50 mm. Frisk sentinel node. Enligt min kontaktsköterska så ( fattade jag det som) var de sjuka cellerna ca 10 mm när man lade samman dessa. Min oro nu är för återbesöket som kommer ske i höst, hur vanligt är det med återfall när man haft denna prognosen Grad 3 (schlecht differenziert) - Tumorzellen vom Grad 3 unterscheiden sich sehr stark von normalen Zellen. Sie wachsen schnell in ungeordneter, unregelmäßiger Verteilung. Das Brustkrebs-Staging ist eine Klassifizierungsmethode, die sich nach der Größe des Tumors richtet und berücksichtigt, ob und wie weit sich der Krebs vom ursprünglichen Krankheitsherd in der Brust ausgebreitet hat Ductalt carcinoma in situ er et forstadium til brystkreft. Tilstanden kjennetegnes av at områder i kjertelgangene i brystvevet har økt cellevekst med dårligere kontroll av cellene. Dette kan man påvise ved å ta en vevsprøve (biopsi) og undersøke i mikroskop. Ductalt carcinoma in situ kan også skrives 'duktalt karsinom in situ' og forkortes DCIS
Prognose Wanneer DCIS op tijd wordt opgespoord en behandeld, is de uitkomst meestal goed. De kans op overleving is dan bijna 100 procent. Er bestaat echter een kans dat de tumor weer terugkomt, vooral na een borstsparende operatie zoals lumpectomie en kwadrantectomie DCIS, også betegnet intraduktalt karsinom, må ikke forveksles med invasivt karsinom av duktal type. DCIS er et tidlig stadium av celleforandring som ikke har gått gjennom basalmembranen. Tidligere ble DCIS en sjelden oppdaget og utgjorde kun mellom 1,4 og 5,3 % av alle nydiagnostiserte brystkrefttilfelle Grading of ductal carcinoma in situ (DCIS) determined by size and shape of nuclei and patterning. All DCIS is considered stage 0 breast cancer - or the earliest stage possible. Once DCIS as an early stage cancer is confirmed, it may be given a specific DCIS 'grade' based upon the particular kinds of cells which are growing, the characteristics of their nuclei and their growth patterns dcis graad 4; Info over dcis graad 3. Resultaten van 8 zoekmachines! Web resultaten; Ductaal Carcinoom In Situ - Borstkanker borstkanker.nl. Graad 2 (matig gedifferentieerd DCIS): tussen graad 1 en 3. Graad 3 (weinig of slecht gedifferentieerd DCIS): de cellen zijn sterk afwijkend en delen veelvuldig en ongecontroleerd. Hoewel veel DCIS. DCIS vormt zich in de melkgangen van de borst. DCIS is 'in situ', wat betekent dat het niet is uitgegroeid naar omliggend weefsel. Er komen geen uitzaaiingen voor. Uit DCIS kan wel een invasieve tumor ontstaan, die omliggende weefsels kan binnendringen. Deze vorm kan daarom een voorloper van borstkanker zijn. Lees meer over DCIS
Ductal carcinoma in situ, or DCIS, is a confusing and controversial diagnosis often referred to as stage 0 breast cancer. Here's what you need to know about prognosis, treatment, and the latest. The grades are Grade 1or low grade DCIS; Grade 2 or intermediate grade DCIS; and Grade 3 or high grade DCIS. Also, DCIS can be either estrogen receptor and progesterone receptor positive or negative, meaning that some DCIS is sensitive to estrogen and/or progesterone and some DCIS is not. MYTH No. 2: DCIS does not produce symptoms Indeed, high-grade DCIS is seen with varying degree in all of the ACR Bl RADS suspicious calcification types, including amorphous or indistinct, coarse heterogeneous, and fine pleomorphic forms, though less frequently(>Figure 3). 30,36,37 The challenge for radiologists is most evident in early stages when high-grade DCIS lesions are small and more confined; the appearance of associated. 3. Size, Grade, and Hormone Receptor Status Matter. When assessing the risk of recurrence after surgical removal of DCIS, the size of the lesion is very important. If the total size of the DCIS is determined to be greater than 20 to 25 millimeters, additional treatment—including radiation and hormone therapy—will generally be recommended HER2 is a well-established prognostic and predictive factor in invasive breast cancer. The role of HER2 in ductal breast carcinoma in situ (DCIS) is debated and recent data have suggested that HER2 is mainly related to in situ recurrences. Our aim was to study HER2 as a prognostic factor in a large population based cohort of DCIS with long-term follow-up
Nuclear grade I/II (ie, low-grade) DCIS was diagnosed in 54.5% of patients. The percentage of patients with a Charlson comorbidity score of at least 2 was significantly higher in the SV group. DCIS is graded based on what the cells look like under the microscope. They will be given a grade according to how different they are to normal breast cells and how quickly they are growing. DCIS is graded as: Low grade - the cancer cells look most like normal breast cells and are usually slow growin Low-grade DCIS is typically associated with amorphous calcifications, whereas high-grade DCIS is more typically associated with pleomorphic and fine linear branching calcifications ( Figures 5.2 and 5.3). However, the mammographic features overlap substantially, and the grade of DCIS cannot reliably be determined by its mammographic features Prognosen er dårlig, med en femårsoverlevelse på 6,1 %. Fortolkning. Diagnosebildet er sammensatt, med både nevrologiske symptomer og kognitive problemer. Fase 3-studier pågår nå, Oppfølgingen må derfor i stor grad tilpasses den enkelte pasient
There were no recurrences among mastectomy patients who scored 4-9 using the USC/VNPI. Patients scoring 10-12 were significantly more likely to develop recurrence after mastectomy. At risk were young patients with large, high-grade, and multifocal or multicentric tumors. For every 100 patients with DCIS is graded based on what the cells look like under the microscope. They will be given a grade according to how different they are to normal breast cells and how quickly they are growing. DCIS is graded as low, intermediate, or high grade. • low grade - the cancer cells look most like normal cells and are usually slow-growin DCIS is given a grade, which describes how DCIS cells look and how quickly they grow compared to normal cells. The 3 grades of DCIS are low, intermediate and high. Knowing the grade is important as it can help doctors predict how likely DCIS will come back after treatment or turn into an invasive breast cancer Ductal carcinoma in situ (DCIS) is non-invasive breast cancer. Ductal means that the cancer starts inside the milk ducts, carcinoma refers to any cancer that begins in the skin or other tissues (including breast tissue) that cover or line the internal organs, and in situ means in its original place But I—along with most doctors —would not recommend that you wait for a year to be treated. Not all DCIS is the same and your grade of DCIS—ll/lll is more likely to go on to become invasive cancer. Many people would estimate the risk for this type of DCIS to be between 50% and 60%, rather than 30%
En transgen musemodell for det ductal karsinom in situ (dcis) av brystkjertelen - onkogen - Onkogen - 202 In DCIS, the grade of the cells is important. It indicates how likely DCIS is to come back in the breast. It also indicates how likely it is to develop into an invasive cancer. There are three grades: Grade 1 (low-grade cancer) The cancer cells look similar to normal cells (they are well differentiated)
DCIS grade III. Plasma cell mastitis DCIS special forms 25 % Malignancy rate 96% Dominant mass Architectural Galactographic distortion finding. Grade 1 / distribution in 108 cases of Grade 3 Tinctures of Dexterity. Medicine NGSS and Common Core Integration - Grade 3 Disciplinary Core Ideas There's already plenty of evidence that even a low-grade DCIS allowed to sit around in situ may eventually burst its boundaries. Here's an article that helpfully puts its conclusions in the title: Continued observation of the natural history of low-grade ductal carcinoma in situ reaffirms proclivity for local recurrence even after more than 30 years of follow-up But it might not be necessary if you have only a small area of DCIS that is considered low grade and was completely removed during surgery. Hormone therapy. Hormone therapy is a treatment to block hormones from reaching cancer cells and is only effective against cancers that grow in response to hormones. Ductal carcinoma in situ (DCIS) is the presence of abnormal cells inside a milk duct in the breast. DCIS is considered the earliest form of breast cancer. DCIS is noninvasive, meaning it hasn't spread out of the milk duct and has a low risk of becoming invasive The lesion was associated with high-nuclear grade DCIS, and displayed solid and cribriform growth patterns with associated comedonecrosis and microcalcifications. The two lymph nodes that were removed were both positive for metastatic carcinoma; in one, the cancerous deposit measured 1.3 cm, and in the other, 1.6 cm (Figure 4)
DCIS can be any size, but will always be described as stage 0. This is the earliest stage with no invasive breast cancer. The grade of the cancer The grade of a cancer describes how the cells look compared with normal cells under the microscope. This gives doctors information about how quickly the cancer might grow or spread Calculation. The index is calculated using the formula: . NPI = [0.2 x S] + N + G. Where: S is the size of the index lesion in centimetres; N is the node status: 0 nodes = 1, 1-3 nodes = 2, >3 nodes = 3; G is the grade of tumour: Grade I =1, Grade II =2, Grade III =3; Interpretatio For DCIS at low risk of progression to invasive cancer, such as low-grade, small, nonpalpable lesions, there may be no benefit to surgery and radiation, whereas for large, palpable, high-grade.
Nevertheless, it has been estimated that only 3% to 8% of women die of breast cancer within the first 20 years of receiving a diagnosis of DCIS. A small minority (0.5%) of women with DCIS eventually progress to stage IV breast cancer without ever being diagnosed with an in-breast invasive tumor Duktal karsinom in situ (DCIS) er en ondartet, klonal proliferasjon av celler som vokser i brystmassebondens bundet strukturer og uten tegn på invasjon i omkringliggende stroma. Når mammografisk brystseks screening ikke utføres, utgjør DCIS ca. 5% av brystkreftene, men innenfor screeningsprogrammer består den av ca. 20-25% av disse svulstene If DCIS is suspected, a biopsy is usually required to confirm whether DCIS is present. Pathologists usually attribute a grade to DCIS. The grade indicates the patterns of cancer cell growth and how fast the cells are growing. Based on what the DCIS cancer cells look like under a microscope, DCIS can be graded as high, intermediate or low The Van Nuys Prognostic Index: offers a more tailored prognosis than the one size fits all treatment approach. It is based on size & grade of DCIS, margins and age of patient. DCIS patients with scores of 4, 5 or 6 can be considered for treatment with excision only. Patients with scores (7, 8, or 9
A good risk cancer was defined as DCIS that occurred in only one place in the breast, had a low or intermediate nuclear grade (determined by the size and shape of the cell's nucleus), was less than 2.5 centimeters and had been removed with a clear margin around it that was at least 3 millimeters wide They found that most DCIS lesions were ER-positive, especially in well and moderately differentiated (grades 1 and 2) tumors. However, a large fraction of grade 3 DCIS lacked ER expression. ER expression was also less marked among cases with comedonecrosis. 2 Diab 3 determined the concordance between ER status of DCIS and invasive disease in. This lowers the chance of the cancer coming back in the same breast (either as more DCIS or as an invasive cancer). BCS without radiation therapy is not a standard treatment, but it might be an option for certain women who had small areas of low-grade DCIS that were removed with large enough cancer-free surgical margins. Mastectom I know this sounds perhaps a bit aggressive for low grade but the DCIS was quite extensive. My surgeon says we are ahead of the game, and I agree, but I'd feel more at ease to be 100% cured (if that's possible) and have it all taken away. I am 48. Has anyone else had low grade but extensive DCIS, and if so, what did your medical team reccomend
Hvis det er spredning til mellom 1 og 3 lymfeknuter er prognosen ca. 50%. Hvis 4 eller flere lymfeknuter er angrepet, er sannsynligheten for å være i live 10 år etter diagnosen nede på ca. 25%. Andre ting påvirker også fremtidsutsiktene How can DCIS (in situ) also be focally suspicious for microinvasion? What does a nuclear grade of 2-2/3 mean to the patient? Read 2 Responses. Follow - 0. 2 Responses boninclyde. Mine was DCIS but dr. was sure he would find invasion. During surgery he did. Not sure about the grade Grade 3: The cancer grade is sorta meaningless when it is all DCIS and didn't spread. My own DCIS was grade 3 with comedo necrosis. Nothing invasive. Therefore, my own treatment was exactly the same as a Grade 1 or Grade 2 patient. The grade literally made no difference for anything in my cancer journey Had my pre op today went well really need to start taking note off what they say sooooo much to take in I haven't got dcis I have invasive - 781112. Browse Sign In Help. Breast Cancer Care Forum. Talk to our breast care nurses 0808 800 6000. 66713 members. 241 online. 351845 post Among 194 patients with DCIS, with a median follow-up of 54 months, the actuarial 5-year incidence of local recurrence was 3.4%. Notably, nearly 50% of the DCIS lesions has comedonecrosis.
Brustkrebsspezifische Mortalität 3,3 % Erhöht bei jungen Frauen und schwarzer Rasse Patientinnen mit invasiven Rezidiven haben eine ungünstigere Prognose quoad vitam HR 18 (95%CI, 14,0-23,6) Die Reduktion von invasiven Rezidiven durch Radiotherapie verbessert nicht das Überleben nach 10 Jahren Original Investigatio DCIS (Ductal Carcinoma in Situ) may comprise up to 30% of all breast cancer diagnoses. But is it really cancer? It is listed as Breast Cancer, Stage 0 and alternative cancer sources say that stage zero is a pre-cancerous state. Know what you're dealing with before you agree to major surgery or chemotherapy
There is a grading system for in situ of breast cancer and Dr. Harness explains that there are three grades - high grade, intermediate grade, and low grade t.. DCIS is diagnosed when the cells that line the milk ducts turn malignant, but are unable to penetrate through the wall of the duct (noninvasive), so cannot get into the lymph nodes or blood stream. There is currently controversy about whether DCIS should be called breast cancer at all I had 15mm IDC grade 2 and then 2 areas totalling 54mm of grade 3 DCIS. Luckily for me I am (was) a 36D and my surgeon carried out a lumpectomy. I had 80mm cut out and although I have a large dent, they went in from the left and the dent is there, so in a bra it isn't noticeable that I have this dent been shown to be detected in greater amounts around DCIS grade 3 than DCIS grade 1  and DCIS associated stromal changes might play a role in progression to IDC . The boxes were extracted at magnification level ×10. The deep learning system developed to grade DCIS takes into account the inter-observer variability in DCIS grading I am a survivor of DCIS. I had it two years before diagnosis. If left untreated by a period of 3 to 5 yrs , it can become invasive & spread to other parts of body. Insitu --- means to stay unless untreated. Edit --- I was told by my oncologist that DCIS is the earliest form of breast cancer. After mastectomy it has a 10% chance of returning.
Higher grade DCIS appears more likely than lower grade DCIS to progress to invasive cancer after treatment (surgery, with or without radiation therapy) . With close follow-up, invasive breast cancer is usually caught early and can be treated effectively Histopathological grading diagnosis of ductal carcinoma in situ (DCIS) of the breast may be very difficult even for experts, and it is important for therapeutic decisions. The challenge may be due to the inaccurate and/or subjective application of the diagnosis criteria. The aim of this study was to investigate the intra-observer agreement between a traditional method and a developed web-based. The oldest is the phase III randomized LORIS trial launched in 2014 by Cancer Research UK. 3 Women aged 46 years and older who recently received a diagnosis of DCIS not classified as high grade. Hallo Ingrid, ich hatte auch ein DCIS(=ductales Carcinoma in situ, was bedeutet, dass sich das Ca 'nur' in den Milchgängen ausgebreitet ha Die Brustkrebs-Heilungschancen sind gut, wenn der Tumor frühzeitig entdeckt und behandelt wird. Daneben gibt es viele weitere Faktoren. Lesen Sie alles über die Brustkrebs-Prognose
I was dx with DCIS on Dec 11th and had a lumpectomy on Dec 17th. The margins were clear but close on one side so the surgeon wants to go back in and take more out to have a wider margin. Mine was stage 0 grade 2. Quite a large area was removed 10x8x4 cm. He said I would most probably have radiation and Amiridex(sp?) for 5yrs Figure 3. Lymph nodes associated with breast cancer spread. DCIS prognosis. The prognosis of DCIS depends on various factors including tumor size, grade (how abnormal tumor cells look on microscopy) and histology of the tumor (how the tumor appears under a microscope), margin width (represents completeness of excision) and presence of necrosis (cell death) within the tumor Therefore, Sagara et al 3 question the need and benefit for surgical excision of low-grade DCIS. We urge physicians to exercise caution when generalizing this population-based cohort analysis to current practice. There are inherent limitations to population-based cancer data with regard to specific patient and tumor characteristics Radiation Therapy Reduces the Risk of DCIS but Increases the Risk of Side Effects. One of the most common questions I receive on PeopleBeatingCancer is from one of the 60,000 women who have been diagnosed with Ductal Carcinoma In-Situ (DCIS- breast cancer stage 0)- if they should have radiation after their lumpectomy- after they surgically remove the abnormal cells that caused the DCIS diagnosis
The breast cancer recurrence after completion of DCIS treatment may occur as DCIS again (non-invasive)or other cancer (invasive). This risk can be measured by half-half or 50-50 chances. American Cancer Society estimated that every year 60,000 DCIS cases are diagnosed in the USA and that denoting almost 1 out of every 5 new breast cancer cases High grade DCIS has a slightly greater recurrence risk than low or intermediate grade DCIS. . 6. What is the significance of the reported size of the ductal carcinoma in-situ (DCIS)? The extent of DCIS can be difficult to measure under the microscope Remember that to try and guess the grade of DCIS on the mammogram images is not plausible or reproducible. Low grade DCIS is not a dangerous disease and there is actually some thought on following the disease with MRI after a histological diagnosis has been made. DCIS is not a single entity, but rather a spectrum of disease 3 Grade 3: Nuclei >3x size of RBC. Necrosis usually present. Notes: It is often hard to find RBCs when you want 'em. DCIS is pleomorphic. If no RBCs are present to compare with compare the nuclei to one another. If you see nuclei >3x larger than their neigbour you're ready to call DCIS Grade 3. Size criteria for low-grade DCIS Die Prognose des DCIS bezüglich Rezidivrate korrelliert gut mit dem Indexwert. Das DCIS entsteht fast immer an einer Stelle in der Brust, breitet sich aber oft nicht kontinuierlich aus, so dass der Eindruck entsteht, es sei an verschiedenen Stellen gleichzeitig entstanden. Sprünge von bis zu einem Zentimeter sind möglich
They concluded that there was no survival advantage to undergoing surgery in cases of low grade DCIS. For patients with intermediate grade DCIS, 10 year breast cancer specific survival rates were 98.6% in the group who underwent surgery vs 94.6% in the non-surgical group. For patients with high-grade DCIS, 10 year breast cancer specific. Entsprechend der Prognose können die Patientinnen in drei Gruppen eingeteilt werden: negative axilläre Lymphknoten, 1-3 positive axilläre Lymphknoten, 4 und mehr positive axilläre Lymphknoten. Das Auftreten von Mikrometastasen (< als 2 mm im Durchmesser) scheint von untergeordneter prognostischer Bedeutung zu sein
Similar margin widths were favored in patients with DCIS. 4 Finally, a survey of 702 radiation oncologists from North America found that 45.9% regarded no tumor on ink as a negative margin; margin widths of 1, 2, 3, 5, and 10 mm were considered negative by 7.4%, 21.8%, 10%, 10%, and 4.9% of respondents, respectively. In DCIS cases, the cancer cells develop within the milk ducts and remain within these breast ducts (in Situ). Because of its confinement to the breast ducts, it is considered non-invasive, giving minimal probability of becoming invasive. Symptoms of Ductal Carcinoma in Situ (DCIS) Most of the times, DCIS doesn't show any signs or symptoms 3. Size < 15 mm. 16-40 mm >41 mm. Margins >10 mm. 1-9 mm < 1 mm. Pathologic. Classification. Non-high grade without necrosis (nuclear grade 1 and 2) Non-high grade with necrosis (nuclear grade. Il DCIS è una forma iniziale di tumore al seno (detto anche precancerosi, pre-invasivo, intraduttale): le cellule tumorali si sviluppano all'interno dei dotti ma rimangono in situ cioè non si estendono al di fuori del dotto nel tessuto circostante o in altre parti del corpo. Questa caratteristica rende la prognosi del DCIS molto buona.. Molto raramente anche gli uomini possono. Dabei wird auch der Entartungsgrad des DCIS ermittelt - von Grad 1 oder G1 (niedriges Risiko: entwickelt sich in 30 Prozent der Fälle zu Brustkrebs) bis hin zu Grad 3 oder G3 (hohes Risiko: geht unbehandelt sehr häufig in Brustkrebs über). Video: DCIS Breast Cancer: Learn What You Need To Know (September 2020)
Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - DCIS, Low Grad Treatment options for DCIS depend on a number of things, including the size of the DCIS compared to the size of the breast, the grade of DCIS, the woman's age and whether she has a family history of breast cancer. Because ductal carcinoma in situ (DCIS) may develop into invasive breast cancer and invasive breast cancer can spread and cause death, it's recommended that al Women who had high-nuclear-grade DCIS lesions had an increased risk of recurrence as invasive cancer compared with women who had low-nuclear-grade lesions (OR = 2.3, 95% CI = 0.9 to 5.6) (data not shown) Death rates were higher for women diagnosed before age 35 than for older women (7.8 percent versus 3.2 percent), and higher for African Americans than for Caucasians (7 percent versus 3 percent). The mean age at diagnosis among women in the study was 54 years old, and less than 1.5 percent of the women with DCIS were under age 35 The mortality rate reported here is lower than rates reported in the past. 3,7,10 In the 20-year follow-up report of the Sweden DCIS randomized trial (1046 women who received a diagnosis of DCIS between 1987 and 1999), the breast cancer-specific mortality rate was 1.8% at 10 years and was 3.9% at 20 years. 10 In a previous study of DCIS cases from the SEER program, the 10-year breast cancer.
DCIS is categorized by grade: Low-grade DCIS moves slowly, with cells that look similar to normal breast cells, and is unlikely to recur after surgery. Moderate-grade DCIS grows more rapidly and starts to fill up the ducts, while high-grade DCIS grows so rapidly that it can be seen dividing under a microscope I wrote about surgery for DCIS about a month ago. The controversy continues. The JAMA Oncology study by Dr. Steven Narod and colleagues used the SEER Database to try to determine if treatment for DCIS improves the death rate. They found that breast cancer-specific mortality was approximately 3.3% over a 20 year period, a very low rate
Die Prognose kann je nach Typ kann eine gute aber auch schlechtere sein. Muzinöses, tubuläres und papilläres Mammakarzinom: Die 3 verschiedenen Arten von Mammakarzinom gehören je mit 1-2% der zu den seltenen Brustkrebsarten. Gewebetypen. Die Mehrzahl von diesen Tumoren mit günstiger Differenzierung (Grading 1) haben eine sehr gute Prognose Prognosen ved kols er en gradvis forverring av sykdommen. De fleste kols-pasienter opplever etter noen år med sykdommen at den begrenser daglige gjøremål. Fysisk aktivitet blir tyngre, og det skal stadig mindre til før en blir tungpusten